Then, we found that when miR-197-3p was downregulated, cell proliferation was enhanced (all p<0.01) (Fig 4B) while apoptosis was degraded (all p<0.01) (Fig 4C), indicating that downregulation of miR-197-3p reversed the effect of silencing LINC01857 on reducing cell proliferation and improving apoptosis in HCC. The gene discussed is LINC01857; the disease is hepatocellular carcinoma.