There are 3 possible theories for CAM related to immune and inflammatory processes: (1) COVID-19 causes significant lymphopenia, resulting in a dramatic reduction in the availability of T cells (CD4+ and CD8+) and opening the entry gate for opportunistic fungal infections; (2) increased pro-inflammatory markers in patients with severe disease; and (3) pronounced damage of pulmonary tissues by COVID-19 aids the invasive fungi, especially the airborne ones or those that attack through the respiratory system [47,48]. The gene discussed is CD4; the disease is COVID-19.