Although this unexpected finding did not allow us to analyze the influence of Rsk2 deficiency on osteosarcoma development, we unexpectedly observed a remarkable accumulation of trabecular bone in the femur and humerus midshaft region of Trp53Cre mice, which did not appear in Rsk2-deficient Trp53Cre mice. Here, RPS6KA3 is linked to osteosarcoma.