Both SmLEV1 and SmLy6B, however, are non-cryptic antigens and elicit a dominant IgG1 response in-line with the response to other EV antigens such as the aforementioned Sm-TSP-2 [23] and Glyceraldehyde 3-Phosphate Dehydrogenase [37] both of which has been identified as potential schistosomiasis vaccine candidates [46,47]. This evidence concerns the gene THBS2 and schistosomiasis.