The notion of EPHB2 (which encodes the bi-directional ephrin receptor B2) as a MR of the BMI-associated adipose cell state is consistent with the literature that has linked EPHB2 expression to lipid metabolism in prostate tumor cells and adipose ephrin signaling to obesity in mice [39,40]. Here, EPHB2 is linked to obesity due to melanocortin 4 receptor deficiency.