ACE2 and infection: While several species of bats are currently perceived as the most consequential animal host of SARS-CoV-2, our data suggest that other animals, either clades or several species within a clade, may have had ancestral exposures to SARS-like viruses that have resulted in evolutionary adaptations at the ACE2-spike interface that may confer some form of tolerance or resistance to infections from SARS-like viruses.