We observed that most subsets of CD8+ T cells induced coinhibitory programs, and CD8-C1 CD69+ Trm cells, CD8-C4 exhausted CD8+ T cells, and CD8-C5 FOSB+ CD8+ T cells from right-sided CRC induced stronger coinhibitory programs compared with those from left-sided CRC (Figure 5G). This evidence concerns the gene CD8A and colorectal carcinoma.