In parallel processing of transcriptomic data using IPA, we recognized that there was also a heavy gene set weighting toward Notch and Wnt signaling pathway genes among the most significant gene sets, such as “breast cancer regulation by stathmin1,” “CREB signaling in neurons,” “hepatic fibrosis signaling pathway,” “tumor microenvironment pathway,” “basal cell carcinoma signaling,” and “hepatic stellate cell activation” (Supplemental Figure 12A). Here, CREB1 is linked to neoplasm.