PRKDC and limb ischemia: While Snhg12 expression appears to play an important role in the angiogenic response in acute limb ischemia, the mechanism by which this occurs is not solely explained by its interaction with DNAPK and its role in vascular senescence, suggesting a role in cellular proliferation, growth pathways, response to VEGF, endothelial sprouting, or the response of skeletal muscle and the EC compartment to ischemia.