Despite increased baseline levels of inflammation in diabetic models of obesity, there was no difference in tissue accumulation of leukocytes as measured by CD45 and no changes in M1-like or M2-like macrophage polarization as measured by CCR7 or CD206 expression by immunofluorescence (Supplemental Figure 9D). The gene discussed is PTPRC; the disease is obesity due to melanocortin 4 receptor deficiency.