Early after acute limb ischemia, SNHG12 levels were decreased by 78%–86% in the endothelial cell (EC) and significantly decreased by 93%–95% in non-EC compartments of gastrocnemius muscle in C57BL/6 mice at days 4 and 7, during a time that correlates with acute inflammation and initial wound healing responses involving EC interaction with inflammatory cells, fibroblasts, and smooth muscle cells. Here, SNHG12 is linked to limb ischemia.