In sharp contrast to the Lyz2-K2KO mice with KLF2 deficiency in both macrophages and neutrophils, the Cx3cr1-Cre–driven KLF2-KO mice (designated Cx3cr1-K2KO) did not manifest severe cardiac hypertrophy in response to 4-week AngII infusion (Supplemental Figure 3). Here, AGT is linked to cardiac hypertrophy.