Furthermore, given that the reduction in KLF2 expression in neutrophils is observed from both clinical HF patients and experimental HF mice (Figure 1) and that KLF2 reduction is known to enhance proinflammatory myeloid cell activation (39), we sought to validate whether this pathogenic pathway is operative in WT animals, where the KLF2 gene is not deleted, but rather its expression is reduced in the setting of disease. Here, KLF2 is linked to hydrops fetalis.