Smaller hemoglobin increments associated with RBC units from female donors heterozygous for G6PD deficiency alleles (n = 46) compared with those with WT alleles (n = 2584) were also statistically significant (0.81 ± 0.35 g/dL versus 0.93 ± 0.30 g/dL, P = 0.04; Figure 3). Here, G6PD is linked to hyperinsulinemic hypoglycemia, familial, 4.