To investigate the possible mechanism by which low expression of miR-582-3p acts as a tumor suppressor gene in OC, we achieved overexpression or silencing of expression of miR-582-3p in OC cells through the transfection of miRNA mimics or inhibitors, and then examined the effects of these alterations on the proliferation and migration of ovarian cancer cells. This evidence concerns the gene ENSG00000280371 and ovarian carcinoma.