While CMV-reactive cells remained within, though somewhat shuffled, the same effector/memory transcriptional phenotypes between unexposed and COVID-19 cohorts (including chronic stimulation, cytotoxic terminal effector, and terminal effector memory), we observed a striking shift of EBV-specific cells from chronic stimulation and central memory into the “CD127+ memory” state in COVID-19-exposed individuals. This evidence concerns the gene IL7R and COVID-19.