While many miRNAs are predicted to target individual genes, only a few miRNAs, to date, have been shown to directly target SHP-2 in immune cells (Li et al. 2007) and in certain cancers (Patel et al. 2016, Cai et al. 2018, Long et al. 2018); none of which have reported roles in human placenta (Liang et al. 2007). This evidence concerns the gene PTPN11 and cancer.