HDAC1 and pachyonychia congenita: They regulate histone deacetylation (HDAC1, 2, 3, 6), DNA methylation (DNMT1, 3A, 3B), histone methylation (KDM1A, ‐4A, ‐5C, ‐6A, EZH2, PRMT5), and transcriptional repressors (ERG, FOXA1), but SNAI2 expression is not correlated with AR expression in either primary (TCGA) or metastatic PC tumors (SU2C and FHCRC) (Fig. S5A).