First, CD148 is down‐regulated in cancer cells or neoplastic tissues, including thyroid, breast, renal, cervical, gastric, and pancreatic cancers,4, 5, 6, 7, 8, 9 while CD148 is upregulated on the differentiation of cancer cells5, 10 or with the cancer‐protective nutrients.11 This evidence concerns the gene PTPRJ and pancreatic neoplasm.