MAPK3 and cancer: In support of CD148's tumor suppressing activity, a body of literature has shown that CD148 dephosphorylates growth factor receptors and their signaling molecules that play a major role in cancer cell growth, including epidermal growth factor receptor (EGFR),9, 14, 15, 16, 17 hepatocyte growth factor receptor (HGFR),18 platelet‐derived growth factor receptor‐β (PDGFRβ),19, 20 vascular endothelial growth factor receptor‐2 (VEGFR‐2),15, 16, 21 ERK1/2,22, 23 PLCγ1,6, 24 and p85 subunit of PI3‐kinase.25