Second, introducing CD148 into cancer cells strongly suppresses their cell proliferation and colony formation in culture and tumor growth in vivo, including breast, thyroid, pancreatic, renal, lung, gastric and colon cancer cells,4, 5, 6, 7, 9, 10, 11, 12 while CD148 knockdown promotes cancer cell proliferation and migration in culture and tumor growth in vivo.7, 8, 9, 11, 13. The gene discussed is PTPRJ; the disease is cancer.