CD68 and cancer: They are highly heterogeneous and multifunctional,[30, 31, 32] but their origins are still largely unknown.[33] The present study is the first to investigate the implication of MMT in cancer, revealing a direct mechanism of TAM for promoting CAF generation using well‐established lineage tracing strategies.[6, 8, 9, 24, 36] In this study, we demonstrated the existence of MMT in cancer by identifying their co‐expression of TAM (CD68) and CAFs (α‐SMA) markers in the lung, kidney, and prostate cancers.