In concordance, we observed that transfer of BMDM‐MMT markedly promoted the CAF formation (α‐SMA+ cells; Figure 4C) and angiogenesis (CD31, collagen, type I (Col‐I), and basic fibroblast growth factor (bFGF); Figure 4D) in the LLC‐bearing NOD/SCID mice, resulting in a dramatic acceleration of tumor growth in vivo (Figure 4E; Figure S10, Supporting Information). This evidence concerns the gene PECAM1 and neoplasm.