Recently, we have identified a TGF‐β1/Smad3‐dependent mechanism in MMT in kidney diseases, where macrophages serve as a rich source for generating the fibrotic myofibroblast de novo.[8, 9, 10, 24] Nevertheless, the potential role of MMT in the Smad3‐TME is still unexplored. The gene discussed is SMAD3; the disease is kidney disorder.