SMAD3 and cancer: Transcriptome signatures and phenotypes are highly dynamic in the TME, where TAM were transcriptionally distinct from monocytes and tissue‐resident macrophages due to the cancer cells.[18, 19] The scRNA‐seq helps to dissect reconstituted temporal transcription networks in response to developmental processes and/or external stimuli, which can be masked at the population level.[20, 21, 22] Elucidating the Smad3‐TME at the single‐cell resolution can be a promising research strategy for identifying how TAM promote CAF formation in cancer.