Furthermore, when various cytokines that contribute to cancer cachexia—such as TGF‐β, IL‐6, and tumor necrosis factor alpha (TNF‐alpha)—are inhibited, bone mineral density loss is attenuated, most likely by preventing full differentiation of osteoclasts through the RANK–RANKL pathway.30, 31, 32. Here, TNFRSF11A is linked to cancer.