CAT and neoplasm: Besides, Fe3+ ions coordinated in porphyrin‐based PCN‐224(Fe) MOFs served as catalase‐like nanozymes, which not only catalyzed the decomposition of H2O2 to O2 to alleviate tumor hypoxia (Figure 12b), but also suppressed other pathways consuming generated ROS by intracellular GSH depletion.