The effect of hypoxia on cell adhesion has been reported for other cell types and seems to be cell type- and adhesion substrate-specific, as hypoxia increases the adhesion of lymphocytes to mesenchymal cells [35] and neutrophils to the endothelium [36, 37] and inhibits the adhesion of several tumor cell lines to fibronectin, collagen type I, and vitronectin [38]. This evidence concerns the gene FN1 and neoplasm.