PTBP1 and brain neoplasm: PTBP1 has the ability to drive brain tumour growth and invasiveness [18], exemplifying the importance of PTBP1 inhibition by Pnky. Other prominent lncRNAs such as RMST (rhabdomyosarcoma 2–associated transcript) [52], TUNA (Tcl1 Upstream Neuron-Associated lincRNA) [41] and Dali (DNMT1-Associated Long Intergenic) [6] also function in neurogenesis by physically interacting with proteins important for the regulation of neural gene expression.