The IMPDH2S280C mutation appeared in a BRAFV600E-mutated patient with a subsequently recurrent thyroid cancer, and the PFKFB4Y366C mutation occurred on a background NRASQ61K mutation, whereas the DICER1D1810H mutation occurred in a patient with no BRAF/RAS mutation. The gene discussed is BRAF; the disease is thyroid gland carcinoma.