GJA1 and epilepsy: Dysfunction of specific astrocytic membrane channel proteins, such as potassium channel Kir4.1, water channel aquaporin 4, glutamate transporters, or gap junction (GJ) protein connexin 43 (Cx43), which is the main GJ protein in astrocytes, has been reported to be involved in the pathophysiology of epilepsy (Patel et al., 2019).