BRAF and melanoma: Based on widely used QC metrics, we conclude that our RNA- and ATAC-seq data accurately reflect the in vivo transcriptional and chromatin accessibility state of the average premalignant BRAF/p53 mutant melanocyte and melanoma cell and provide an important and broadly useful tool for further investigating transcriptional and epigenetic programs underlying these related but crucially different pre- and fully malignant states.