To characterize the genome-wide chromatin accessibility of premalignant Tg(BRAFV600E)/p53lf/lf mutant melanocytes and melanoma, we isolated premalignant melanocytes (mCh+) from four zebrafish, including three MC_Het and one sample from a Tg(BRAFV600E)/p53lf/lf/Tg(MiniCoopR; mitfa:mCherry) zebrafish (MC_Homo). This evidence concerns the gene MITF and melanoma.