Melanocyte and NC programs are particularly active in melanoma cells, with increased sox10 and mitfa expression, respectively, seen in the RNA-seq data (Figure 2E), and this appears consistent with enrichment of SOX9/10 (SOXE family) and MITF (E/M-boxes) binding sites in more accessible regions in melanoma (Figure 3C). The gene discussed is MITF; the disease is melanoma.