EPCAM and neoplasm: IL-2 Immunocytokines have been generated that target extracellular matrix proteins of the tumor vasculature such as the splice isoforms of fibronectin (extra domains A and B) [52–57] and A1 domain of Tenascin C [58–60] or to overexpressed surface antigens including carcinoembryonic antigen (CEA) [61], epithelial cell adhesion molecule (EpCAM) [62], programmed death-ligand 1 (PD-L1) [63, 64], epidermal growth factor receptor (EGFR) [65], disialoganglioside (GD2) [62, 66, 67], and CD20 [68].