IL6 and type 2 diabetes mellitus: Similar results were reported in humans by Dekkers et al. [34], who evaluated the renoprotective effect of dapagliflozin, an SGLT2i, by determining tubular and inflammatory markers in patients with T2DM, reporting that compared to placebo, there is a decrease in urinary excretion of IL-6 and KIM-1 by 23.5% and 22.6%, respectively, suggesting that this drug improves renal inflammation and decreases ischemia in cells of the PT.