However, recessive (CC + CT vs. TT) and overdominant (CC + TT vs. CT) models showed a significant association between IL-1β rs1143634 SNP and HT development risk so may be protective and risk factors against the development of HT, respectively (P = 0.03, OR = 0.67, 95%CI = 0.21 − 0.91; P = 0.03, OR = 1.1, 95%CI = 0.76 − 1.8, respectively). The gene discussed is IL1B; the disease is hematocrit.