Such comparison resulted in 4 upregulated (CP, CEACAM5, DMBT1, and KRT6A) and 8 downregulated (CEL, CPA1, CPB1, ALB, SERPINA4, CA2, CLU, and AMBP) DEGs secreted in cyst fluid of high-risk IPMNs (Figure 5). The gene discussed is CA2; the disease is cyst.