Similarly, genetic reduction of elastin through deletion of a single copy of the gene ELN (supravalvular aortic stenosis—SVAS, OMIM #185500) or deletion of ELN as part of a 25–27 coding gene microdeletion of chromosome 7 (Williams syndrome, OMIM #194050) leads to increased pulse wave velocity and hypertension (3–5). This evidence concerns the gene ELN and Williams syndrome.