For example, POLE/POLD1 gene mutations are associated with microsatellite instability (MSI), mismatch repair (MMR), and TMB, and CMTM6 is related to PD-L1 expression and regulation of anti-tumor immunity (Burr et al., 2017; Yao et al., 2019). The gene discussed is CMTM6; the disease is neoplasm.