PPI links connecting to key metabolic enzymes, such as RRM2, NDUFA11, ENO2, EZH2, AKR1C2, and TYMS, are identified from signaling proteins (e.g., PPARD, BAD, GNB5, CHECK1, PAK2, PLK1, BRCA1, MAML3, and SPP1), TFs (e.g., KAT2B, ING1, MED1, ZEB1, AR, NCOA2, EGR1, TWIST1, E2F1, ID4, RBL1, ESR1, and HSF2), and miR (e.g., mir-147a, mir-593-5p, mir-138-5p, mir-16-5p, and mir-15b-5p) in cervical cancer scenario. Here, E2F1 is linked to cervical cancer.