However, 17 metabolic enzymes (EZH2, MTHFD1, ALDH3B2, ATP6V1B1, TCIRG1, AGMAT, SETDB1, PFKL, TKT, INPPL1, MTHFD2, CPS1, MARS, PFKP, AASDHPPT, ATP6V0D2, and PLOD3) connected to nine deregulated metabolites (L-lysine, adenosine monophosphate, fructose 6-phosphate, homovanillic acid, methylimidazole acetic acid, N-acetylglutamic acid, phenylacetic acid, phosphate, and Urea) were found to be commonly regulated in ovarian cancer. This evidence concerns the gene MTHFD1 and ovarian carcinoma.