Furthermore, some of these genes, such as CD1C, TNFSF10, PARVG, NID1, DHRS12, ITPK1, ACSF3, and TNFRSF13C, also show a differentiated methylation signature in SLE patients (Ballestar et al., 2020; Fang et al., 2021). This evidence concerns the gene ACSF3 and systemic lupus erythematosus.