The KEGG signaling pathways enriched by downregulation were Hippo signaling pathway (mmu04390, p = 3.24E-02, 9 genes), tight junction (mmu04530, p = 2.31E-02, 7 genes), thyroid hormone signaling pathway (mmu04919, p = 0.022, 8 genes), gap junction (mmu04540, p = 0.019, 7 genes), HIF-1 signaling (mmu04066, p = 0.012, 8 genes), dopaminergic synapse (mmu04728, p = 0.005, 10 genes), Alzheimer’s disease (mmu05010, p = 0.0004, 14 genes), and Parkinson’s disease (mmu05012, p = 0.0003, 13 genes) (Supplementary Figure 4B). This evidence concerns the gene TG and early-onset autosomal dominant Alzheimer disease.