SOAT1 and depressive symptom measurement: Moreover, there is also direct evidence from studies in populations with depressive disorders, suggesting that JAK/STAT pathways may be involved in the pathophysiology of depression and the antidepressant actions of current treatments have been shown to be mediated by JAK/STAT-dependent mechanisms (Wen et al., 2009; Lee et al., 2015; Shariq et al., 2019).