Subdoligranulum which contains the butyrate kinase gene is a direct source of energy source for colonic epithelium, and anti-inflammatory properties (vegetarian children and IBD) as a result of the inhibition of NF-κB (Chumpitazi et al., 2014; Matijasic et al., 2014; McNabney and Henagan, 2017). The gene discussed is NFKB1; the disease is irritable bowel syndrome.