Hence, we systematically and comprehensively investigated the molecular contributions of HOXD10 methylation in CRC, with a goal to identifying the targets of HOXD10 to promote colorectal carcinogenesis, finding evidence that indicates the link between HOXD10 and chemoresistance, and deciphering whether HOXD10 and its targets may have translational relevance as therapeutic targets. This evidence concerns the gene HOXD10 and colorectal carcinoma.