In this study, we explore the effect of overexpression of Glo1 in the antiproliferative activity of clinical antitumor agents, the contribution of MG-induced cytotoxicity in cancer chemotherapy and mechanism of MG increase and cytotoxic response, and Glo1 expression as a risk predictor on cancer chemotherapy outcomes in clinical breast cancer. This evidence concerns the gene GLO1 and breast carcinoma.