A similar approach was used by Bartoletti et al. [13] who demonstrated that age, obesity, body temperature, RR, lymphocytes, CRP, creatinine, and LDH>350 IU/L, considered together in the so-called PREDI-CO score, have good accuracy in predicting severe respiratory failure (SRF) (AUROC 0.89, sensitivity 80% and specificity 76% at a score>3 points). The gene discussed is CRP; the disease is Obesity.