BRCA2 and breast cancer: If an unaffected man has a personal history of male breast cancer or exocrine pancreatic cancer, Ashkenazi-Jewish ancestry, a probability of > 5% of carrying a BRCA2 pathogenic variant based on a probability model, having a first or second-degree relative with any of the following: breast cancer aged ≤ 45, breast cancer aged 46–50 with a second breast cancer diagnosed at any age, breast cancer aged 46–50 with ≥ close blood relative with breast, pancreatic, ovarian or prostate cancer [61].