KLK3 and pure red-cell aplasia: The PROFILE study (https://clinicaltrials.gov/ct2/show/NCT02543905) is in progress, examining the role of upfront MRI and prostate biopsy (regardless of PSA) in men aged 40–69 from two high-risk groups: 350 men with a FH of PrCa and 350 men of Afro-Caribbean descent.