KLK3 and cancer: They demonstrated that compared with offering biopsy to all men with a PSA > 3.0 ng/mL, the STHLM3 model decreased overdiagnosis by avoiding 32% of prostate biopsies without significantly decreasing sensitivity to detect high-grade disease (Gleason ≥ 7) and reducing the number of low-grade cancers (Gleason ≤ 6) detected by 17% [80].