Of these, integrin-linked kinase (ILK)has become one of the most important and fascinating such molecules.Discovered in 1996 by Dedhar and co-workers as a integrin-β1subunit binding protein,2 ILK has beenknown to be a kinase for a long time.2−5 However, as its crystal structure revealeda pseudoactive kinase catalytic site (PDB ID: 3KMW), this putativeactivity as a protein kinase has been questioned and become quitecontroversial.6−9 Nonetheless, studies with this molecule have led to its validationas a promising therapeutic target for cancer.3,10,11. This evidence concerns the gene ILK and cancer.