Compared to the nontransfected UC-MSCs, when miR-133 inhibitor transfected UC-MSCs cocultured with PBMCs of ITP, the induction of B10 cells decreased obviously; correspondingly, the induction of CD19+/CD24hi/CD38hi B cells also decreased remarkably. The gene discussed is CD19; the disease is autoimmune thrombocytopenic purpura.