Although MSCs have been shown to inhibit immune cell activation, reduce inflammatory cytokines, and induce autoimmune tolerance and have already been used as treatment methods [46], the exact regulating mechanism on how SDF-1α controls MSCs in inducing Breg differentiation of ITP still requires more and intensive research, especially involving with miRNA-133 expression. Here, CXCL12 is linked to autoimmune thrombocytopenic purpura.