To determine whether UC-MSCs could induce the Breg generation from peripheral B cells of ITP, we found that the MSCs significantly promoted the generation of CD19+CD24hiCD38hi B cells (2.01 ± 0.46% vs. 5.42 ± 0.53%) and IL-10-producing B cells (2.44 ± 0.58% vs. 5.78 ± 0.86%) (Figures 1(c) and 1(d)).Cocultured MSCs with B cells can increase the IL-10 level, especially at the ratio of 1 : 1 (180.05 pg/mL ± 23.252 pg/mL). This evidence concerns the gene CD19 and autoimmune thrombocytopenic purpura.