It is generally believed that the expression of RSK2 in cancer tissue is higher than that in normal tissue, and reducing the expression of RSK2 can prevent tumorigenesis, tumor cell growth, and ability of migration and invasion (Lee et al., 2013; Yao et al., 2014; Mao et al., 2016; Zhao et al., 2016). This evidence concerns the gene RPS6KA3 and neoplasm.