High RSK2 expression reduced the possibility of distant metastasis (pooled OR = 0.59, 95% CI: 0.41–0.87, Cochran’s Q test p = 0.88, I2 = 0.0%) (Figure 4A) and lymph node metastasis (pooled OR = 0.81, 95% CI: 0.65–0.998, Cochran’s Q test p = 0.09, I2 = 42.8%) (Figure 4B). Here, RPS6KA3 is linked to metastatic malignant neoplasm in the lymph nodes.