As the center of the adaptive cellular response network, ATF3 participated in tumorigenesis of colon cancer, breast cancer, prostate cancer, liver cancer and lung cancer (Taketani et al., 2012; Wang and Yang, 2013; Wolford et al., 2013; Li et al., 2017; Li et al., 2019). This evidence concerns the gene ATF3 and Familial prostate cancer.