Additionally, the expression of low-density lipoprotein receptor (LDLR) that mediates cholesterol uptake was related to the occurrence and development of breast cancer, pancreatic tumors, glioma, and prostate cancer (Guo et al., 2011; Yue et al., 2014; Guillaumond et al., 2015; Gallagher et al., 2017). Here, LDLR is linked to central nervous system cancer.