In our study, according to the univariate and multivariate analysis results, the clinical value of traditional HCC diagnosis and prognostic indicators such as tumor size/number (Yim et al., 2016; Tzartzeva and Singal, 2018), degree of differentiation, and inflammatory factors (CRP, NLR) (Greten and Grivennikov, 2019; Huang et al., 2019; Chan et al., 2020; Rogovskii, 2020) have been verified. The gene discussed is CRP; the disease is hepatocellular carcinoma.