Interestingly, systemic TLR2 tolerance induced by injecting low-dose Pam2CSK4 significantly enhanced remyelination in a preclinical model of MS, which resulted in the transformation of microglia from pro-inflammatory iNOS+ phenotype to non-inflammatory/pro-repair Arg1+ phenotype (49) (Figure 2). Here, TLR2 is linked to myeloid sarcoma.