Interestingly, the ligand of TLR2 (Pam3Csk4) induces more proinflammatory cytokines including IL-6, IFN-γ, IL-17 and GM-CSF than the ligand of TLR4 (LPS) and TLR9 [oligodeoxynucleotide (ODN)] from CD4+ and CD8+ T cells of MS (Figure 2). This evidence concerns the gene CD4 and myeloid sarcoma.