In relation to those patients with clinical manifestations of APS (APS and non-APS groups), seven patients were triple positive (LA, IgG/IgM aCL, and/or aβ2GPI, as well as IgG aPS/PT) versus only one triple-positive patient in the SLE/Others group (Figure 1). This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.