RAC1 and viral infectious disease: The results suggested that non-enveloped HEV may indirectly trigger the RAC1 signaling pathway being involved in the viral infection as observed for other viruses (Krautkramer et al., 2004; Krzyzaniak et al., 2013; Swaine and Dittmar, 2015; Dun et al., 2020; Kolenda et al., 2020).