As shown in Figures 2C,D, co-culture with iBMSC or stimulated by NB cells-priming iBMSC CM resulted in an up-regulation of phosphorylated STAT3 and ERK1/2 in NB cells with IL6R-expressing, but not in IL6R-deficit NB cell (SH-SY5Y). This evidence concerns the gene STAT3 and neuroblastoma.