CRP and infection: Since the CRP represents an inflammatory acute phase reactant, its level is susceptible to a variety of acute or chronic infections, anti-infective and anti-inflammatory drugs and autoimmune diseases, so that an increase of CRP at least twice during the 2-week interval of ICI administration, together with low levels of procalcitonin, and no evidence of infection (culture and serology) have been suggested as predictors of irAEs (Abolhassani et al., 2019).