Since the CRP represents an inflammatory acute phase reactant, its level is susceptible to a variety of acute or chronic infections, anti-infective and anti-inflammatory drugs and autoimmune diseases, so that an increase of CRP at least twice during the 2-week interval of ICI administration, together with low levels of procalcitonin, and no evidence of infection (culture and serology) have been suggested as predictors of irAEs (Abolhassani et al., 2019). The gene discussed is CRP; the disease is autoimmune disease.