Finally, a common genetic variant of HLA haplotype, HLAdrb1*11:01, has been observed in a retrospective study as related to itching, and may be a possible future biomarker predictive for skin toxicity (Hasan Ali et al., 2019), as well as HLA genotypes dominated by DR4 were described in patients with anti-PD-1/PD-L1-induced type 1 diabetes (Stamatouli et al., 2018). Here, CD274 is linked to type 1 diabetes mellitus.