Hence targeting both EpCAM and Wnt/β-catenin can not only inhibit tumor growth but also prompt tumor infiltration without affecting T-cell survival and enhances the response to EpCAM CAR T, making it an ideal strategy to reactivate intra-tumoral Teff cells and transform a “cold” immune microenvironment into a “hot” one. The gene discussed is EPCAM; the disease is neoplasm.