Although the pathological process of AD is extremely complex and has not been fully elucidated so far, it is known that the typical pathological features of AD are the formation and deposition of extracellular β-amyloid (Aβ) and intracellular neurofibrillary tangles formed by the excessive phosphorylation of Tau protein in neurons, causing a series of reactions, such as the release of inflammatory factors, energy metabolism disorders, and oxidative stress in neurons, and eventually, leading to the degeneration and loss of neurons in cerebral cortex and hippocampus (Reitz et al., 2011). The gene discussed is MAPT; the disease is Alzheimer disease.