In our previous research, UL122 mice displayed significant cognitive impairment compared with the control group, and this appearance was related to the abnormal expression of several genes including Cx43, NMDA, fibroblast growth factor 2 (FGF2), neuron-specific nuclear protein (NeuN), glial fibrillary acidic protein (GFAP), SYP, and PSD-95. This evidence concerns the gene SYP and Cognitive impairment.